Characterization of Cholinergic System Dysregulation in the McGill‐R955‐hTau Rat Model of Human‐Like Tauopathy

The McGill-R955-hTau rat model demonstrates cholinergic dysfunction at advanced stages of brain tauopathy, independent of amyloidosis. Our findings highlight a tau-mediated cholinergic synaptic loss and an accelerated dysregulation of the NGF metabolic pathway previously linked only to amyloidosis or neuroinflammation. These findings offer a further insight into the mechanistic relationship between tauopathy and cholinergic system atrophy in the progression of AD pathology.