Segmentation and Quantification of Perivascular Spaces in Early Alzheimer’s Disease using Ultra‐long TE T2‐weighted MRI
Fluid-specific PVS imaging can be performed within clinically feasible scan times. Early results show strong visual and quantitative sensitivity towards PVS. Furthermore, individuals with AD show increased lobar to subcortical PVS volume ratio compared to CU both on visual assessment and with quantitative evaluation. Ongoing future directions include implementing variant sequences with improved motion robustness and longitudinal follow-up to evaluate the effects of anti-amyloid therapy on PVS.
Authors
- Ilya M. Nasrallah (ORCID: https://orcid.org/0000-0003-2346-7562)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Laura Schankel
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- Long Xie
- Manuel Taso (ORCID: https://orcid.org/0000-0003-2405-9165)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Chris Brown (ORCID: https://orcid.org/0000-0003-1490-6287)
- F Brad Johnson
- Paul A. Yushkevich
- Emily McGrew
- Valerie E Humphreys
- Danielle Hing
- Dawn Mechanic‐Hamilton
Institutions
- Siemens (United States) (US)
- Siemens Healthcare (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108886
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00