Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: Insights from multicenter data
This application of mixed-effects ABNs reveals that accounting for inter-center heterogeneity is critical for accurately modeling risk factor dependencies in multicenter IA cohorts. This approach yields a more parsimonious network structure by reducing spurious associations found in pooled models. By disentangling patient-level effects from center-specific variations, the model enhances predictive power for heterogeneous variables and provides more reliable, clinically interpretable insights into IA pathophysiology, advancing the potential for personalized risk assessment.
Authors
- Isabel C. Hostettler (ORCID: https://orcid.org/0000-0002-9004-2540)
- Reinhard Furrer
- Sandrine Morel (ORCID: https://orcid.org/0000-0003-1538-3553)
- Georg Spinner (ORCID: https://orcid.org/0000-0001-9640-8155)
- Philippe Bijlenga (ORCID: https://orcid.org/0000-0002-3586-2757)
- Svenja Maschke (ORCID: https://orcid.org/0000-0002-7071-7213)
- Maria Wostrack (ORCID: https://orcid.org/0000-0001-6439-3665)
- Marian Christoph Neidert (ORCID: https://orcid.org/0000-0003-2828-4706)
- Matteo Delucchi (ORCID: https://orcid.org/0000-0002-9327-1496)
- Sven Hirsch (ORCID: https://orcid.org/0000-0002-5678-4110)
- David John Werring (ORCID: https://orcid.org/0000-0003-2074-1861)
- Antti Lindgren (ORCID: https://orcid.org/0000-0002-1264-7667)
- Oliver Bozinov
- Ynte M. Ruigrok
- Mark K. Bakker
- Henry Houlden
- Bernhard Meyer
- Romain Bourcier
Institutions
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Queen Mary University of London (GB)
- University of Eastern Finland (FI)
- ZHAW Zurich University of Applied Sciences (CH)
- University of Zurich (CH)
- University of St.Gallen (CH)
- TUM Klinikum (DE)
- Stroke Association (GB)
- University Medical Center Utrecht (NL)
- Kuopio University Hospital (FI)
- University Hospital of Zurich (CH)
- University Hospital of Geneva (CH)
- Institut du Thorax (FR)
- Ostschweizer Kinderspital (CH)
- University College London (GB)
- Technical University of Munich (DE)
- Geneva College (US)
Publication Details
- Journal
- Computers in Biology and Medicine
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1016/j.compbiomed.2025.111380
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00