Mitochondria‐nucleus crosstalk characterizes Alzheimer's disease across 1,5 million brain cells
By integrating multiple layers of biological data from established reference atlases, our analysis of mitochondria-nuclear crosstalk revealed distinct transcriptional signatures associated with AD risk in glial and neural cells, with these associations exhibiting sex-biased patterns.
Authors
- Chloé Savignac (ORCID: https://orcid.org/0000-0002-7730-8324)
- Jack Stanley (ORCID: https://orcid.org/0000-0002-5018-3592)
- Anwesha Bhattacharya
- L. M. Hodgson (ORCID: https://orcid.org/0009-0001-8462-9863)
- Danilo Bzdok
Institutions
- Mila - Quebec Artificial Intelligence Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_096286
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00