Tracking structural changes in preclinical and prodromal Alzheimer’s disease: insights from amyloid‐beta pathology
Our study suggests that brain structural changes in response to Aβ pathology start decades before symptoms and may follow highly nonlinear trajectories. The initial increases in CT and decreases in MD<sub>T</sub> might be related to the space taken by Aβ and/or several other biological processes occurring during the preclinical stage of the disease, such as neuroinflammation, astrocytic and microglia activation, or brain swelling.
Authors
- Yuanchao Zhang (ORCID: https://orcid.org/0000-0001-8191-4899)
- Alex Valcourt Caron (ORCID: https://orcid.org/0000-0002-1206-6395)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- Zhen‐Qi Liu
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Maxime Descôteaux
- Jonathan Gallego Rudolf
- Ting Qiu
- R. Nathan Spreng
- Manon Edde
- Alexa Pichet Binette
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Université de Sherbrooke (CA)
- University of Electronic Science and Technology of China (CN)
- Lund University (SE)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- Alzheimer Society of Canada (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110868
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00