Distinct contributions of cerebrospinal fluid biomarkers to cognitive impairment and neuropsychiatric symptoms in young-onset dementia
Tau-related neurodegeneration (P-tau181 and T-tau) appears more closely linked to memory impairment in YOD than axonal injury markers such as NfL. In non-AD dementias, T-tau was additionally associated with behavioural symptom severity, suggesting tau-related mechanisms across subtypes. These associations require validation in larger, longitudinal, and multimodal studies to clarify temporal and mechanistic pathways.
Authors
- Charles Benjamin Malpas (ORCID: https://orcid.org/0000-0003-0534-3718)
- Wei‐Hsuan Chiu (ORCID: https://orcid.org/0000-0002-5066-2999)
- Wendy Kelso (ORCID: https://orcid.org/0000-0001-5418-6080)
- Dhamidhu Eratne (ORCID: https://orcid.org/0000-0002-3226-7645)
- Dennis Velakoulis (ORCID: https://orcid.org/0000-0002-8842-8479)
- Matthew J.Y. Kang
- Anita M.Y. Goh
- Mark Walterfang
- Samantha M. Loi
Institutions
- Edith Cowan University (AU)
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- National Ageing Research Institute (AU)
Publication Details
- Journal
- Acta Neuropsychiatrica
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1017/neu.2025.10051
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00