Mild Cognitive Impairment and Early Alzheimer's Diseased Explained by 21st Century Model of the Neural Synapse as a Transistor

All critical synaptic BJT components and their function are altered in MCI and early AD. MCI and early AD are characterized by decreased DHA (decreasing electron and hole conduction through the P SC), altered glutamate receptors (affecting the intrinsic power supply to the synaptic BJT), and hyperphosphorylated Tau affecting electrical bias mostly via changes in electrochemical properties of the interstitial matrix which forms the base terminal of the transistor. These processes are independent of tangles and plaques from late AD.