The Gut‐Brain Connection: How Age, Sex, and APOE ε4 Influence Probiotic Balance in Early Alzheimer's Disease
Age, sex, and APOE ε4 status significantly influence gut microbiota composition and SCFA production at the preclinical stage of AD. Reduced butyrate levels, particularly in older female APOE ε4 carriers, highlight the importance of gut health in mitigating AD risk. These findings suggest targeted probiotic interventions could restore gut balance and delay AD progression.
Authors
- Stephanie Ruth Rainey‐Smith (ORCID: https://orcid.org/0000-0001-7328-9624)
- Ralph N. Martins (ORCID: https://orcid.org/0000-0002-4828-9363)
- Samantha Ramachandra (ORCID: https://orcid.org/0000-0002-8833-9273)
- Warnakulasuriya M.A.D.B. Fernando
- Sithara Udeshini Dissanayaka
- Hamid R Sohrabi
Institutions
- Edith Cowan University (AU)
- Murdoch University (AU)
- Cooperative Research Centre for Mental Health (AU)
- KaRaMinds (AU)
- Australian Alzheimer’s Research Foundation (AU)
- Dementia Australia (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_096704
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00