T1w/T2w Ratio reflects microstructural integrity in Alzheimer’s Disease
These findings show that the T1w/T2w ratio is not solely a marker of myelin integrity, but a broader indicator of cortical tissue integrity in AD. Furthermore, the T1w/T2w ratio distinguishes control from AD brains and can regionally differentiate between clinical subtypes. This expanded understanding could improve its application in both research and clinical settings.
Authors
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Wilma DJ van de Berg
- Niels Reijner
- Daniëlle Toen
- Laura Jonkman
- Betty M. Tijms
- Frederik Barkhof
- Louise van der Weerd
Institutions
- Leiden University (NL)
- University of Applied Sciences Leiden (NL)
- AMN Healthcare (United States) (US)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109777
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00