Genetic modifiers of TDP‐43 proteinopathy in FTLD‐TDP and LATE‐NC
A variant in UNC13A appears to increase risk of FTLD-TDP relative to LATE-NC, while a variant in RERG appears to decrease risk; this is directionally concordant with previously reported associations of these variants with FTLD-TDP versus healthy controls. The potential implications of polygenic contributions to prognosis are an important area for future investigation.
Authors
- V. Van Deerlin
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Seth D. Talyansky
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- Nadia Dehghani (ORCID: https://orcid.org/0000-0002-0385-7267)
- Eddie B. Lee
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_107942
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00