Multimorbidity and Cognitive Trajectories in Resource‐Limited Settings: Real‐World Evidence from a Brazilian Public Memory Clinic
In this real-world LMIC sample, multimorbidity was pervasive, and cerebrovascular, neurosensory and substance abuse burdens emerged as significant contributors to dementia risk and accelerated cognitive decline. Low education, common in LMICs, further amplified brain health vulnerability. Findings underscore the need for interventions at primary care levels to mitigate progression and reduce the overall dementia burden in resource-limited settings.
Authors
- Maria Rosa Alves da Silva (ORCID: https://orcid.org/0000-0001-9570-3996)
- Lorenza Pabst Botton
- Lucas Porcello Schilling (ORCID: https://orcid.org/0000-0002-9923-6982)
- Andrei Bieger (ORCID: https://orcid.org/0000-0002-6669-2834)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Alessandra Dalla Rosa Santini
- Fernando Jacob Lazzaretti
- Andressa de Oliveira Felício
- Julia Patatt
- BARBARA SUMAN BAHLIS
- Álvaro Righi de Leonço
- Eduarda Faresin
- Maria Lúcia Hristonof
- Fabricio Nery Garrafiel
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
- Hospital São Lucas da PUCRS (BR)
- Global Brain Health Institute (US)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_101604
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 0.00