Distinct PINK1‐PRKN mitophagy alterations in different primary tauopathies
Our study highlights distinct mitophagy alterations in primary tauopathies that are associated with specific tau inclusions in neurons, oligodendrocytes, and astrocytes. The observed pathological heterogeneity and complex mitophagy disruption underscores the need for future studies to elucidate pathogenic mechanisms and advance targeted therapeutics for each tauopathy.
Authors
- T Chen
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Xu Hou (ORCID: https://orcid.org/0000-0003-3011-4378)
- Fabienne C. Fiesel (ORCID: https://orcid.org/0000-0002-1919-9676)
- Wolfdieter Springer (ORCID: https://orcid.org/0000-0002-1178-3149)
- Shunsuke Koga
- Melissa E. Murray
- S. Tiemann
- Julian Rubiano
- Hannah Hompesch
Institutions
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108879
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00