Prognostic Value of Circulating Tumor Cells and Cancer Associated Macrophage-Like Cells in Metastatic Non-Small Cell Lung Cancer Patients: A Retrospective Exploratory Analysis
Dynamic monitoring of CTCs and CAM-Ls provides actionable prognostic information in metastatic NSCLC. CTC-negative status predicted longer OS and PFS, while CAM-L positivity at T1 was associated with improved outcomes, particularly in ICI-treated patients. Combined assessment of both biomarkers may directly inform therapeutic decision-making, through early detection of outcomes.
Authors
- Michela De Meo (ORCID: https://orcid.org/0000-0002-3024-2233)
- Marco Siringo (ORCID: https://orcid.org/0000-0002-0489-1790)
- Chiara Nicolazzo (ORCID: https://orcid.org/0000-0002-2551-8979)
- P. Gazzaniga
- Alain Jonathan Gelibter
Institutions
- Policlinico Umberto I (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- Link Campus University (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-12-23
- DOI
- https://doi.org/10.32604/or.2025.069832
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00