Sex Differences in APOE Variation and Neurocognitive Health in Older Black Americans

Studying within-group differences in Black Americans will allow researchers and clinicians to better tailor interventions, improve diagnostics, and gain deeper understanding of the complexities of cognitive abilities in this population. Here we report sex differences in how the APOE gene is linked to cognitive performance. Recognizing and exploring within-groups is crucial for identifying specific factors that influence brain health and developing personalized prevention and intervention strategies. Factors such as age, education, and lifestyle choices can lead to diverse cognitive outcomes even among people who appear to be similar.