Associations between Alzheimer's disease polygenic risk and postoperative delirium: a prospective cohort study
Higher AD-PRS is independently associated with an increased risk of POD in adults without dementia. The predictive value of AD-PRS remained consistent across sleep burden levels, sexes, and age groups. These findings highlight the role of polygenic Alzheimer's risk, beyond APOE-ε4, in delirium susceptibility after surgery, but prospective surgical cohorts are needed to confirm these biobank findings.
Authors
- Arlen Gaba
- Yun Jin Chen (ORCID: https://orcid.org/0009-0000-3935-8841)
- Laiyuan Gao (ORCID: https://orcid.org/0000-0002-0563-9896)
- Kun Hu (ORCID: https://orcid.org/0000-0002-1219-1655)
- Peng Li
- Hui‐Wen Yang
Institutions
- Tufts Medical Center (US)
- Harvard University (US)
- Tzu Chi University (TW)
- Queen's University (CA)
- Massachusetts General Hospital (US)
- Hualien Tzu Chi Medical Center (TW)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_101679
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00