HSP90β as a potential prognostic biomarker in urothelial carcinoma: insights from NF-κB, IL-8, and heat-shock protein expression
HSP90β expression shows potential as a prognostic biomarker and therapeutic target in UC. Although NF-κB and IL-8 did not demonstrate consistent prognostic value, their patterns highlight the role of inflammatory signaling in tumor biology. These findings warrant validation in larger, more diverse cohorts and support exploration of HSP90-targeted strategies in UC.
Authors
- Magdalena Bodnar (ORCID: https://orcid.org/0000-0003-3748-1058)
- Łukasz Szylberg (ORCID: https://orcid.org/0000-0003-1349-5906)
- Jędrzej Borowczak (ORCID: https://orcid.org/0000-0001-9873-3285)
- Edyta Podemska
- Małgorzata Drobnik
- Aleksandra Gawrych
Institutions
- Bydgoszcz University of Science and Technology (PL)
- Nicolaus Copernicus University (PL)
- University of Bydgoszcz (PL)
- Antoni Jurasz University Hospital (PL)
- AGH University of Krakow (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1007/s12094-025-04181-9
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00