Sex‐specific effects of estradiol on regional amyloid‐β, white matter integrity, and hippocampal‐dependent memory in cognitively unimpaired older adults
These findings suggest decreased estradiol in women over 60 is associated with increases in entorhinal Aβ accumulation and reduced MTL white matter integrity, which may confer sex-specific deficits in hippocampal-dependent memory. These biomarkers may reflect AD risk unique to women, with potential to help narrow the window for intervention.
Authors
- Emily Yi
- Dana M. Parker
- Jenna N. Adams (ORCID: https://orcid.org/0000-0002-6702-3851)
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- Soyun Kim
- Lisa M. Taylor
- Elizabeth A. Thomas
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108819
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00