A human iPSC‐derived neurosphere model to study functional and transcriptomic properties of microglial neuroprotection in AD
We developed a human 3D neurosphere model to study microglial responses to Aβ pathology. In this model, microglia acquire a neuroprotective phenotype which may be enhanced by anti-Aβ antibodies. Microglia are essential for driving the transcriptomic profile linked to AD after severe Aβ treatment. By mimicking critical AD pathological features, this model offers a platform to identify therapeutic targets with translational relevance.
Authors
- Hyun B. Choi (ORCID: https://orcid.org/0000-0003-2405-4428)
- Haakon B. Nygaard (ORCID: https://orcid.org/0000-0001-5085-4723)
- Sarah N. Ebert
- Brian A. MacVicar (ORCID: https://orcid.org/0000-0003-4596-4623)
- Jonathan Frew
- Mathias Delhaye (ORCID: https://orcid.org/0009-0001-3479-5417)
- Konstantina Karamboulas
- Christopher J. Groten (ORCID: https://orcid.org/0000-0002-6063-7295)
- Faith G. Miller (ORCID: https://orcid.org/0000-0001-9229-4066)
- Yanyang Bai (ORCID: https://orcid.org/0000-0002-9923-6843)
- Wenji Cai (ORCID: https://orcid.org/0009-0003-1127-6571)
- Ada J. Lin
- Stefan Wendt
- Christopher Lee
- Da Young Kong
- David R Kaplan
- Declan J Brennan
- Stefano Sorrentino
Institutions
- University of British Columbia Hospital (CA)
- University of British Columbia (CA)
- Opal-Rt Technologies (Canada) (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098607
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00