Class-II-aldolase-mimicking polyfunctional Lewis acid/azolium–aryloxide catalysts in direct enantioselective nitro-aldol additions
A polyfunctional Co( ii )/azolium–aryloxide catalyst enables direct highly enantioselective Henry reactions. Synergistic Lewis acid, Brønsted base and H-bond activation mimics class-II aldolases, which is supported by DFT and microkinetic modelling.
Authors
- Khushbu Jangid
- Radhika Kataria
- Alexander Allgaier (ORCID: https://orcid.org/0009-0006-0689-6858)
- Johannes Kästner (ORCID: https://orcid.org/0000-0001-6178-7669)
- René Peters (ORCID: https://orcid.org/0000-0002-6668-4017)
- Justin Herrmann
- Daniel M. Wanner
- Lisa A. Schmoltzi
- Janis Gschwind
- Silvio Münch
- Joris van Slageren
Institutions
- University of Stuttgart (DE)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1039/d5qo01558h
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Studienstiftung des Deutschen Volkes