LC‐EC Tract Degeneration is associated with Entorhinal Tau and Memory in Autosomal‐dominant Alzheimer’s Disease
We observed LC-EC tract degeneration in cognitively unimpaired mutation carriers, particularly in females. This degeneration was associated with higher entorhinal tau and poorer cognition, starting several years before symptom onset. LC-EC tract degeneration temporally aligns with previously reported emerging memory decline, highlighting it as a potential early disease vulnerability marker.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- David Fernando Aguillon (ORCID: https://orcid.org/0000-0003-2283-536X)
- Rosalinda Medrano
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Irina Gonzalez (ORCID: https://orcid.org/0000-0003-4570-1313)
- Elouise A. Koops (ORCID: https://orcid.org/0000-0002-4105-4254)
- Nikole A Bonillas Félix
- Sergio Castro Álvarez
- Lusiana Martinez
- Averi Giudicessi
Institutions
- Boston University (US)
- Harvard University (US)
- Maastricht University (NL)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Hospital Pablo Tobon Uribe (CO)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108445
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00