Hippocampal Amyloid‐Beta And Tau Distributions Differentially Affect Cognition In Centenarians
In the oldest-old, PART and ADNC are less distinguishable by determinants observed in younger individuals: centenarians with ADNC may show age-related Aβ accumulation alongside PART-like pTau patterns, while centenarians meeting PART criteria do not always show PART-like pTau patterns. However, hippocampal Aβ-burden and parahippocampal pTau-burden associate with cognitive decline, highlighting subregional-specific vulnerability to pathology-driven cognitive decline.
Authors
- Annemieke J.M. Rozemüller (ORCID: https://orcid.org/0000-0003-2528-4428)
- Timothy E. Richardson (ORCID: https://orcid.org/0000-0001-7068-5517)
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Jamie M. Walker (ORCID: https://orcid.org/0000-0003-1263-7394)
- Maruelle C. Luimes
- Myke E. van der Hoorn
- Susan K. Rohde
- Henne Holstege
- Jeroen J.M. Hoozemans
- Marieke J.I. Graat
- Marc Hulsman
- Dominique A.H. Daatselaar
Institutions
- Roche (Switzerland) (CH)
- Netherlands Institute for Neuroscience (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Vrije Universiteit Amsterdam (NL)
- Delft University of Technology (NL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_096283
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00