Role of physical fitness in resistance and cognitive resilience against age‐related pathology
We demonstrated that aerobic fitness is related to lower BG-PVS volumes in old age and showed that aerobic fitness tends to act as CR proxy against MTL tau pathology. Aerobic fitness may help maintain cerebrovascular and glymphatic dysfunction in old age, thereby mitigating cognitive decline.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Joanna Marguerite Wardlaw (ORCID: https://orcid.org/0000-0002-9812-6642)
- Anne Hochkeppler
- Jose Bernal Moyano
- Michael Rullmann (ORCID: https://orcid.org/0000-0002-2683-9432)
- Andrew Stephens (ORCID: https://orcid.org/0000-0001-5052-6586)
- Anne Maaß (ORCID: https://orcid.org/0000-0002-7889-795X)
- Niklas Vockert (ORCID: https://orcid.org/0000-0001-5915-2517)
- Osama Sabri
- Berta Garcia‐Garcia (ORCID: https://orcid.org/0000-0002-8585-6507)
- Svenja Schwarck (ORCID: https://orcid.org/0000-0003-2024-9236)
- Larissa Fischer (ORCID: https://orcid.org/0009-0001-9936-2954)
- Enise I. Incesoy (ORCID: https://orcid.org/0000-0003-2014-4098)
- Hermann Esselmann (ORCID: https://orcid.org/0000-0001-5484-9710)
- Bárbara Morgado (ORCID: https://orcid.org/0000-0001-8174-9301)
- Michael C. Kreißl (ORCID: https://orcid.org/0000-0001-5905-6015)
- Andreas Schildan (ORCID: https://orcid.org/0000-0002-9418-3826)
- Beate Schumann‐Werner (ORCID: https://orcid.org/0000-0002-3530-5766)
- Eóin N. Molloy (ORCID: https://orcid.org/0000-0002-7804-2214)
- Patrick Müller (ORCID: https://orcid.org/0000-0001-7458-2208)
- Marianne Patt (ORCID: https://orcid.org/0000-0001-6492-4104)
- Maria del C. Valdés Hernández
- Jens Wiltfang
- Roberto Duarte
- Henryk Barthel
- Niklas Behrenbruch
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- University Hospital Magdeburg (DE)
- University of Göttingen (DE)
- Leipzig University (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_099453
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00