Role of physical fitness in resistance and cognitive resilience against age‐related pathology

We demonstrated that aerobic fitness is related to lower BG-PVS volumes in old age and showed that aerobic fitness tends to act as CR proxy against MTL tau pathology. Aerobic fitness may help maintain cerebrovascular and glymphatic dysfunction in old age, thereby mitigating cognitive decline.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_099453
Primary Topic
Traumatic Brain Injury Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Role of physical fitness in resistance and cognitive resilience against age‐related pathology

Emrah Düzel, Joanna Marguerite Wardlaw, Anne Hochkeppler, Jose Bernal Moyano et al.
Alzheimer s & Dementia
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Role of physical fitness in resistance and cognitive resilience against age‐related pathology

Emrah Düzel, Joanna Marguerite Wardlaw, Anne Hochkeppler, Jose Bernal Moyano, Michael Rullmann, Andrew Stephens, Anne Maaß, Niklas Vockert, Osama Sabri, Berta Garcia‐Garcia, Svenja Schwarck, Larissa Fischer, Enise I. Incesoy, Hermann Esselmann, Bárbara Morgado, Michael C. Kreißl, Andreas Schildan, Beate Schumann‐Werner, Eóin N. Molloy, Patrick Müller, Marianne Patt, Maria del C. Valdés Hernández, Jens Wiltfang, Roberto Duarte, Henryk Barthel, Niklas Behrenbruch
article en

Abstract

We demonstrated that aerobic fitness is related to lower BG-PVS volumes in old age and showed that aerobic fitness tends to act as CR proxy against MTL tau pathology. Aerobic fitness may help maintain cerebrovascular and glymphatic dysfunction in old age, thereby mitigating cognitive decline.

Alzheimer s & DementiaVol. 21(S6)
German Center for Neurodegenerative Diseases (DE), Universitätsmedizin Göttingen (DE), University Hospital Magdeburg (DE), University of Göttingen (DE), Leipzig University (DE), Otto-von-Guericke-Universität Magdeburg (DE), University of Edinburgh (GB)
Openalex Percentile: Top 30%
Traumatic Brain Injury Research
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