Sex‐specific associations between Glutaminyl Cyclase and Alzheimer's Disease biomarkers
Our study demonstrates that AC+AP+ positive women had higher QPCT levels than AC+AP+ men. Additionally, stronger correlations between QPCT and imaging biomarkers, particularly FDG and Aβ-PET, were found in women whereas men exhibited associations with hippocampal volume. These preliminary results suggest that, in AC+AP+ women, CSF QPCT protein levels are increased and associated with Aβ-PET and FDG-PET biomarkers.
Authors
- João Batista Teixeira da Rocha (ORCID: https://orcid.org/0000-0003-3829-0595)
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Débora Guerini de Souza (ORCID: https://orcid.org/0000-0003-2982-4989)
- Marcelo Madrid de Bittencourt
- Gabriela Mantovani Baldasso
- Eduardo R. Zimmer
- Gabriel Lermen Hoffmeister
Institutions
- TH Köln - University of Applied Sciences (DE)
- Universidade Federal do Rio Grande do Sul (BR)
- University of Cologne (DE)
- Universidade Federal de Santa Maria (BR)
- Instituto do Cérebro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108965
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00