Brain Age Gap Predicts Progression to Dementia in SCD and MCI

BAG is predictive of progression to dementia in SCD and MCI and has added value over VRS in SCD. This highlights the potential of BAG as a predictor of progression to dementia, especially in early disease stages, when traditional VRS are insensitive.

Authors

Calvin Trieu (ORCID: https://orcid.org/0000-0001-6266-2198)
Mara ten Kate (ORCID: https://orcid.org/0000-0002-8290-8543)
S. de Vries
Frederik Barkhof
Jyrki Lötjönen
Hanneke F.M. Rhodius‐Meester
Wiesje M. van der Flier
Alle Meije Wink
Katalin Farkas
Bas Jasperse

Institutions

Oslo University Hospital (NO)
Amsterdam Neuroscience (NL)
Theranostics (New Zealand) (NZ)
The London College (GB)
Amsterdam University Medical Centers (NL)
University College London (GB)
Vrije Universiteit Amsterdam (NL)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70862_109897
Primary Topic: Dementia and Cognitive Impairment Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Brain Age Gap Predicts Progression to Dementia in SCD and MCI

Calvin Trieu, Mara ten Kate, S. de Vries, Frederik Barkhof et al.

Dec 1, 2025

Alzheimer s & Dementia

Dementia and Cognitive Impairment Research

article

Brain Age Gap Predicts Progression to Dementia in SCD and MCI

Calvin Trieu, Mara ten Kate, S. de Vries, Frederik Barkhof, Jyrki Lötjönen, Hanneke F.M. Rhodius‐Meester, Wiesje M. van der Flier, Alle Meije Wink, Katalin Farkas, Bas Jasperse

December 1, 2025article en

Abstract

BAG is predictive of progression to dementia in SCD and MCI and has added value over VRS in SCD. This highlights the potential of BAG as a predictor of progression to dementia, especially in early disease stages, when traditional VRS are insensitive.

Alzheimer s & DementiaVol. 21(S8)

Oslo University Hospital (NO), Amsterdam Neuroscience (NL), Theranostics (New Zealand) (NZ), The London College (GB), Amsterdam University Medical Centers (NL), University College London (GB), Vrije Universiteit Amsterdam (NL)

Openalex Percentile: Top 36%

Dementia and Cognitive Impairment Research

DOI Open Access PDF OpenAlex

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Brain Age Gap Predicts Progression to Dementia in SCD and MCI — Calvin Trieu, Mara ten Kate, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS