Developing a transcriptomic atlas of Alzheimer's Disease progression in the Tg2576 mouse model using single‐cell RNA‐sequencing technology
These findings provide a single-cell resolution view of AD-related transcriptional changes, supporting a 'vascular angiogenesis model' of AD. Disruptions in blood-brain barrier integrity due to aberrant neoangiogenesis may drive amyloid-beta accumulation, contributing to disease progression. This study underscores the therapeutic potential of targeting vascular dysfunction in AD.
Authors
- Giorgia Caspani (ORCID: https://orcid.org/0000-0003-1697-1437)
- Wilfred A. Jefferies (ORCID: https://orcid.org/0000-0002-7392-9852)
- Chaahat S. B. Singh (ORCID: https://orcid.org/0000-0002-2832-9188)
- Cheryl G. Pfeifer (ORCID: https://orcid.org/0000-0001-8584-228X)
- Kelly Marie Johns
- Maria‐Elizabeth Baeva
- Wing Yan Leung
Institutions
- University of British Columbia (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_097892
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00