<i>In vivo</i> detectability of tau‐PET tracers in Alzheimer’s disease
Tau-PET tracers exhibit significant variability in detectability. [<sup>18</sup>F]MK6240 consistently demonstrated lower NRR, implying better detectability across all regions, cross-sectionally and longitudinally. Despite differences in NRR, [<sup>18</sup>F]FTP, [<sup>18</sup>F]RO948 and [<sup>18</sup>F]PI2620 followed similar pattern. These results provide insights into the differential tracer detectability, helping guide their optimal use in detecting and tracking tau pathology. Ongoing follow-up scans will further clarify longitudinal tracer detectability and its implications for tau progression in AD.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Nesrine Rahmouni
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Jacob Ziontz (ORCID: https://orcid.org/0000-0002-1995-3827)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- David Soleimani‐Meigooni
- Hsin‐Yeh Tsai
- Cécile Tissot (ORCID: https://orcid.org/0000-0002-5022-2213)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- William J. Jagust
- Joseph Therriault
- Brian A. Gordon
- Peiwei Liu
- Stijn Servaes
- William E Klunk
Institutions
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109804
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00