Middle Cerebral Artery Remodelling as a Response to Alzheimer's Disease Proteins

This study demonstrates that tau fibrils induce vascular dysfunction, which has previously been described for Aβ oligomers. The combined effect of these proteins, resembling a more comprehensive model of patient pathology, highlights the importance of targeting vascular disturbances in Alzheimer's Disease and provides insights into potential mechanisms affecting cerebral blood flow during disease progression. We have initiated imaging of vessels mounted in a pressure myograph using a two-photon to examine vascular changes, particularly focusing on structural changes. The protocol with preliminary data is attached in Figure 2.