Pre‐atrophic Neurodegeneration: A Novel MRI‐Based Biomarker for Early Neuronal Injury Coincident with Early Amyloid Accumulation
qGRE-based NDI provides in-vivo microstructural brain neurodegeneration distribution in early amyloid pathology where atrophy is not detectable. Although the NDI parameter reflects neuronal cell density, presence of inflammation can also reduce the NDI value. Thus, further investigations are required to understand the microstructural nature of pre-atrophic neurodegeneration.
Authors
- Dmitriy A. Yablonskiy (ORCID: https://orcid.org/0000-0003-2898-8797)
- Cihat Eldeniz (ORCID: https://orcid.org/0000-0002-4457-0916)
- Satya V.V.N. Kothapalli
- Tammie L.S. Benzinger
- Randall J. Bateman
- Melody Li
- John C. Morris
Institutions
- Washington University in St. Louis (US)
- Hope Center for Neurological Disorders (US)
- Prevent Alzheimer’s Disease 2020 (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108277
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00