National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing

This nationwide survey demonstrates alarmingly high NNRTI resistance but minimal INSTI resistance, underscoring the urgent need to phase out efavirenz-based regimens. Strengthening access to affordable second-generation-based therapies and enhancing prescriber education are critical to sustaining treatment efficacy and preventing further transmission of resistant HIV strains.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2025-11-25
DOI
https://doi.org/10.1093/jac/dkaf444
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing

Luz Marina Sañudo, S. Ávila-Rios, Jaime Álvarez, José Fernando García-Goez et al.
Journal of Antimicrobial Chemotherapy
HIV/AIDS drug development and treatment
article

National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing

Luz Marina Sañudo, S. Ávila-Rios, Jaime Álvarez, José Fernando García-Goez, Claudia García-Morales, Jose Millan Oñate, Ernesto Martínez-Buitrago, Andrés Felipe Zapata-Marín, William Lenis, Margarita Matías-Florentino, Luisa Consuelo Rubiano
article en

Abstract

This nationwide survey demonstrates alarmingly high NNRTI resistance but minimal INSTI resistance, underscoring the urgent need to phase out efavirenz-based regimens. Strengthening access to affordable second-generation-based therapies and enhancing prescriber education are critical to sustaining treatment efficacy and preventing further transmission of resistant HIV strains.

Journal of Antimicrobial ChemotherapyVol. 81(1)
Fundación Valle del Lili (CO), Instituto Nacional de Enfermedades Respiratorias (MX), Universidad del Valle (CR), Fundación General (ES), Spitalul Clinic de Recuperare (RO), Hospital de Clínicas (UY), Corporación de Lucha Contra el Sida (CO), Icesi University (CO), Universidad del Valle (CO)
ViiV Healthcare
Good health and well-being
Openalex Percentile: Top 31%
HIV/AIDS drug development and treatment
DOIOpen Access PDFOpenAlex
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National representative survey of pretreatment HIV drug resistance in Colombia: analysis of antiretroviral resistance-associated mutations using next-generation sequencing — Luz Marina Sañudo, S. Ávila-Rios, et al. · Journal of Antimicrobial Chemotherapy (2025) | TGRS Research Map | TGRS