Investigating laminar distribution of tau or TDP‐43 pathology in frontotemporal lobar degeneration using cortical diffusion MRI
Regional differences suggest that PerpPD<sup>+</sup> can distinguish cortical microstructural changes in FTLD due to tau vs. TDP-43. The correlation between PerpPD<sup>+</sup> values and laminar pathology ratios reinforces that PerpPD<sup>+</sup> is an MRI marker sensitive to tau pathology distribution.
Authors
- Pegah Khosropanah (ORCID: https://orcid.org/0000-0002-5255-7631)
- Daniel T. Ohm (ORCID: https://orcid.org/0000-0002-7930-5434)
- Mario Torso (ORCID: https://orcid.org/0000-0002-5284-9167)
- Gerard R. Ridgway (ORCID: https://orcid.org/0000-0002-7676-7860)
- Steven A. Chance (ORCID: https://orcid.org/0000-0001-6060-3805)
- Hamsi Radhakrishnan
- Eddie B. Lee
- David J. Irwin
- Ian Hardingham
Institutions
- Oxford Medical Diagnostics (United Kingdom) (GB)
- Penn Center for AIDS Research (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110096
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00