Brain‐language coupling: a representational similarity analysis of autobiographical speech and cortical morphometry in healthy aging and prodromal Alzheimer's disease
In cognitively healthy, amyloid-negative older adults, the semantic structure of autobiographical memory partly relates to orbitofrontal, inferior frontal and lateral temporal cortical thickness patterns, with a temporal gradient. This coupling is lost in prodromal AD, likely due to neurodegeneration of lateral temporal regions implicated in autobiographical memory.
Authors
- Patrick Dupont (ORCID: https://orcid.org/0000-0003-1980-2540)
- Bastiaan Tamm (ORCID: https://orcid.org/0000-0001-6094-4060)
- Helena Balabin (ORCID: https://orcid.org/0000-0002-6392-9306)
- Laure Spruyt (ORCID: https://orcid.org/0000-0002-0618-5005)
- Kevin Statz (ORCID: https://orcid.org/0009-0009-7400-7006)
- Rik Vandenberghe
- Stefan Sunaert
Institutions
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108732
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00