Mediating role of aging and obesity in the relationship between dietary index for gut microbiota and metabolic syndrome and its potential regulatory mechanisms

Higher DI-GM scores are linearly associated with a lower risk of MetS and its components, with BMI and KDM-BAA index playing prominent mediating roles. Our study demonstrates the important role of DI-GM in potentially preventing the risk of MetS, and we observe the significant influence of unfavorable factors for gut microbiota in this relationship. It also suggests that the improvement of body weight management and modulation of physiological functions during aging may be key mechanisms in this association. Additionally, TP53 may serve as a novel diagnostic biomarker and potential therapeutic target.