CSF Biomarkers of Neuroinflammation in Prediction of Brain Atrophy
These results suggest that certain biomarkers, particularly the synaptic latent factor and the individual markers sTREM2, ferritin, and YKL40, are predictive of longitudinal neurodegeneration in key brain regions vulnerable to Alzheimer's disease. The associations found with hippocampal and basal forebrain atrophy highlight the potential of these markers for tracking disease progression and improving early detection strategies.
Authors
- Emrah Düzel (ORCID: https://orcid.org/0000-0002-0139-5388)
- Anja Schneider (ORCID: https://orcid.org/0000-0002-3377-5828)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Serap Özlü
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Alice Grazia (ORCID: https://orcid.org/0000-0001-8861-3183)
- Christoph Laske (ORCID: https://orcid.org/0009-0009-3434-936X)
- Luca Kleineidam (ORCID: https://orcid.org/0009-0006-3309-6856)
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Oliver Peters (ORCID: https://orcid.org/0000-0002-0051-4357)
- Josef Priller
- Frederic Brosseron
- Jens Wiltfang
- Martin Dyrba
- Stefan Teipel
- Julian Hellmann‐Regen
- Frank Jessen
- Alfredo Ramirez
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Humboldt-Universität zu Berlin (DE)
- Rostock University of Music and Theatre (DE)
- University of Rostock (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108159
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00