Amyloid‐induced cerebral hypermetabolism drives tau accumulation in early stages of Alzheimer’s Disease
Our results suggest that early-stage Aβ-related hypermetabolism drives tau accumulation already at low centiloid levels, preceding tau positivity in the temporal meta-ROI and decreases as disease progresses. Trials targeting neuronal hyperactivity may be most effective at early-stage Aβ deposition and low fibrillar tau.
Authors
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- M. Brendel
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
- Sebastian N. Roemer‐Cassiano
- Zeyu Zhu
- Anna Dewenter
- Lukas Frontzkowski
- Madleen Klonowksi
Institutions
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108551
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00