ProtBAG: eleven organ‐specific proteome‐based biological age using CSF proteomics
This study leverages CSF proteomics data from ADNI to accurately develop 11 organ-specific ProtBAGs, enriching the organ aging clock framework established in previous literature using plasma proteomics. Future research will investigate the relationship between these ProtBAGs, cognition, and AD progression.
Authors
- Gao T. Wang
- Donald Edmondson (ORCID: https://orcid.org/0000-0002-4518-8196)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Sarah Ko (ORCID: https://orcid.org/0009-0009-8105-3924)
- Hui Cao (ORCID: https://orcid.org/0000-0002-5901-5499)
- Wenjia Bai
- Andrew Zalesky
- Mehrshad Saadatinia
- Junhao Wen
- Arthur W. Toga
- Elisa Konofagou
- Ye Ella Tian
Institutions
- University of Southern California (US)
- University City Science Center (US)
- The University of Melbourne (AU)
- Institute on Aging (US)
- New York Genome Center (US)
- Fujitsu (United Kingdom) (GB)
- Melbourne Health (AU)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110193
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00