High‐resolution postmortem 7 tesla MRI yields localized atrophy measures that are more sensitive to tau pathology and neuronal loss in Alzheimer’s disease than corresponding measures on antemortem 3 tesla MRI
Purple-mri paves the way for large-scale postmortem image analysis. Stronger associations between thickness and average tau burden/neuronal loss than antemortem MRI suggests that our pipeline could inform the development of more precise and sensitive invivo biomarkers by mapping information from postmortem to antemortem MRI in a common reference coordinate system.
Authors
- Alejandra Bahena
- Amanda E Denning (ORCID: https://orcid.org/0009-0005-2531-9346)
- Ranjit Ittyerah
- Daniel T. Ohm (ORCID: https://orcid.org/0000-0002-7930-5434)
- Theresa Schuck
- Pulkit Khandelwal (ORCID: https://orcid.org/0000-0003-1397-3496)
- Sydney Lim (ORCID: https://orcid.org/0000-0002-5359-4661)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- E. B. Lee
- Winifred Trotman (ORCID: https://orcid.org/0000-0002-4121-1889)
- M. Gabrielyan (ORCID: https://orcid.org/0000-0003-4974-4783)
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- John Robinson (ORCID: https://orcid.org/0000-0001-6858-2367)
- Michael Tran Duong (ORCID: https://orcid.org/0000-0003-0312-5530)
- Gabor Mizsei
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Lisa M Levorse
- Karthik Prabhakaran
- Paul A. Yushkevich
- Laura E.M. Wisse
- Ved Shenoy
- Nathaniel Gauthier
- David J. Irwin
- M. Dylan Tisdall
Institutions
- Lund University (SE)
- Penn Center for AIDS Research (US)
- Institute on Aging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109729
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00