Spectris™ treatment is associated with significant time saved in the OVERTURE feasibility and open label extension (OLE) study

The OVERTURE study demonstrated that Spectris treatment significantly reduced the decline of scale points in ADCS-ADL, MMSE and WBV over 6 months compared to sham treatment. Evaluation of the OVERTURE RCT and OLE demonstrated significant time saved up to 18 months of treatment. These outcomes may be meaningful to Alzheimer's patients and their caregivers and are being further evaluated in the ongoing HOPE pivotal trial of Spectris in mild-moderate AD (NCT05637801).

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108303
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Spectris™ treatment is associated with significant time saved in the OVERTURE feasibility and open label extension (OLE) study

Suzanne Hendrix, RALPH DONALD KERN, Joshua R. Christensen, Lily Lee et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Spectris™ treatment is associated with significant time saved in the OVERTURE feasibility and open label extension (OLE) study

Suzanne Hendrix, RALPH DONALD KERN, Joshua R. Christensen, Lily Lee, Matthew Morgan, Marwan N. Sabbagh
article en

Abstract

The OVERTURE study demonstrated that Spectris treatment significantly reduced the decline of scale points in ADCS-ADL, MMSE and WBV over 6 months compared to sham treatment. Evaluation of the OVERTURE RCT and OLE demonstrated significant time saved up to 18 months of treatment. These outcomes may be meaningful to Alzheimer's patients and their caregivers and are being further evaluated in the ongoing HOPE pivotal trial of Spectris in mild-moderate AD (NCT05637801).

Alzheimer s & DementiaVol. 21(S7)
TheraTarget (United States) (US), TetraLogic Pharmaceuticals (United States) (US), Banner Alzheimer’s Institute
Openalex Percentile: Top 36%
Dementia and Cognitive Impairment Research
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