Cardiorespiratory fitness modifies the relationship between cerebral vessel stiffness and white matter hyperintensities in a cognitively unimpaired cohort enriched for Alzheimer's disease risk
Our findings suggest that fitness may be protective against the deleterious relationship between cerebral vessel stiffness and WMH, highlighting potential role for CRF in preserving white matter integrity in an older, cognitively unimpaired cohort enriched for AD risk.
Authors
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Kyle J. Edmunds (ORCID: https://orcid.org/0000-0002-6591-4116)
- Laura B. Eisenmenger (ORCID: https://orcid.org/0000-0001-6764-4239)
- Brianne M. Breidenbach (ORCID: https://orcid.org/0000-0001-6366-9818)
- Alma Spahic (ORCID: https://orcid.org/0000-0002-7322-5871)
- Ira Driscoll (ORCID: https://orcid.org/0000-0002-1737-3343)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Leah E. Symanski
- Ozioma C. Okonkwo
- Leonardo A. Rivera‐Rivera
- Sterling C Johnson
- Sara Fernandes‐Taylor
Institutions
- Reykjavík University (IS)
- Alzheimer's Association (US)
- University of Wisconsin–Madison (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108313
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00