Effect of the ApoE genotype on the efficacy of multidomain lifestyle interventions on cognitive change: a meta‐analysis of three randomized clinical trials
This study provides the first robust evidence that multidomain, lifestyle-based interventions can particularly benefit ApoE4 carriers. Importantly, ApoE4 was shown to modify the effect of the intervention on cognition across different populations (Asian and European) and cognitive groups (at-risk and MCI). Thus, ApoE4 carriers represent a particularly important target group for preventive interventions.
Authors
- Jenni Lehtisalo (ORCID: https://orcid.org/0000-0002-8818-0848)
- M. Kivipelto
- S. Andrieu
- Nicola Coley (ORCID: https://orcid.org/0000-0002-1671-824X)
- Esko Levälahti
- Hidenori Arai
- Tiia Ngandu
- Francesca Mangialasche
- Alina Solomon
- Christelle Cantet
Institutions
- Karolinska University Hospital (SE)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- University of Eastern Finland (FI)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Karolinska Institutet (SE)
- Finnish Institute for Health and Welfare (FI)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- Healthpoint (AE)
- MRC Unit for Lifelong Health and Ageing (GB)
- National Center for Geriatrics and Gerontology (JP)
- Imperial College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_102747
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00