Sex Differences in the Association of Serum Albumin and Cholesterol with Cognitive Function in Older Adults with Cognitive Impairment

Serum albumin and cholesterol are independently associated with cognitive function among older adults with cognitive impairment. Notably, the effect of cholesterol appears to differ by sex, with stronger cognitive impacts observed in women. These findings emphasize the clinical relevance of metabolic and nutritional biomarkers in dementia risk assessment and suggest a potential for gender-specific strategies in cognitive health interventions.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108239
Primary Topic
Nutritional Studies and Diet
Type
article
Field-Weighted Citation Impact
0.00
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article

Sex Differences in the Association of Serum Albumin and Cholesterol with Cognitive Function in Older Adults with Cognitive Impairment

Derong Zeng, Teruaki Kawasaki, Xiaoyu Hong, Ayae Kinoshita et al.
Alzheimer s & Dementia
Nutritional Studies and Diet
article

Sex Differences in the Association of Serum Albumin and Cholesterol with Cognitive Function in Older Adults with Cognitive Impairment

Derong Zeng, Teruaki Kawasaki, Xiaoyu Hong, Ayae Kinoshita, Ichiro Akiguchi, Maolu Yin
article en

Abstract

Serum albumin and cholesterol are independently associated with cognitive function among older adults with cognitive impairment. Notably, the effect of cholesterol appears to differ by sex, with stronger cognitive impacts observed in women. These findings emphasize the clinical relevance of metabolic and nutritional biomarkers in dementia risk assessment and suggest a potential for gender-specific strategies in cognitive health interventions.

Alzheimer s & DementiaVol. 21(S7)
Kyoto University (JP), Peking University Shenzhen Hospital (CN), Kyoto University of Education (JP), Kyoto University Hospital (JP), Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
Zero hunger
Openalex Percentile: Top 27%
Nutritional Studies and Diet
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