“Mitochondrial CA‐V inhibition mitigates Alzheimer’s Disease progression via modulation of neurovascular inflammation and microglia function”
These findings improve our understanding of the function of CA-V in the development of AD pathology and highlight the potential of CA-VB inhibition to improve microglial clearance and reduce brain neuroinflammation. Overall, we demonstrate that mitochondrial CA-V is emerging as a promising target against AD and other cerebrovascular indications.
Authors
- Silvia Fossati (ORCID: https://orcid.org/0000-0002-2047-222X)
- Marc Antoniu Ilies (ORCID: https://orcid.org/0000-0003-0694-411X)
- Nicole L Lemon (ORCID: https://orcid.org/0000-0002-5956-4666)
- Elisa Canepa (ORCID: https://orcid.org/0000-0003-2906-7797)
- Maryam H. Abyaneh (ORCID: https://orcid.org/0009-0008-8428-4595)
- Tina Hirt (ORCID: https://orcid.org/0009-0003-9180-4628)
Institutions
- Temple University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108889
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00