Dantrolene and cyproheptadine as salvage therapy for severe intrathecal baclofen withdrawal: A case report

Therapy options are limited for treatment of severe intrathecal baclofen withdrawal. High-dose dantrolene and cyproheptadine appeared to be well tolerated and improved our patient's symptoms when used as adjunctive therapy along with enteral baclofen and high-dose GABA agents.

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Publication Details

Journal
American Journal of Health-System Pharmacy
Published
2025-12-20
DOI
https://doi.org/10.1093/ajhp/zxaf352
Primary Topic
Botulinum Toxin and Related Neurological Disorders
Type
article
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article

Dantrolene and cyproheptadine as salvage therapy for severe intrathecal baclofen withdrawal: A case report

Shelley S. Glaess, Joseph Oropeza
American Journal of Health-System Pharmacy
Botulinum Toxin and Related Neurological Disorders
article

Dantrolene and cyproheptadine as salvage therapy for severe intrathecal baclofen withdrawal: A case report

Shelley S. Glaess, Joseph Oropeza
article en

Abstract

Therapy options are limited for treatment of severe intrathecal baclofen withdrawal. High-dose dantrolene and cyproheptadine appeared to be well tolerated and improved our patient's symptoms when used as adjunctive therapy along with enteral baclofen and high-dose GABA agents.

American Journal of Health-System Pharmacy
Memorial Hospital (US)
Openalex Percentile: Top 32%
Botulinum Toxin and Related Neurological Disorders
DOISourceOpenAlex
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Dantrolene and cyproheptadine as salvage therapy for severe intrathecal baclofen withdrawal: A case report — Shelley S. Glaess, Joseph Oropeza · American Journal of Health-System Pharmacy (2025) | TGRS Research Map | TGRS