Exploring Digital Maze Performance Features Associated with PET Spatial Extent (EXT) in Cognitively Normal Older Adults
Our findings demonstrate that dMaze features can detect subtle cognitive deficits associated with early amyloid spread even in a CN only sample. While specific CH maze features differentiated individuals without amyloid and with evidence of amyloid spread, unique features on the NC maze were associated with the level of spread within a subthreshold group (EXT+). These results build on work with global amyloid burden by showing that dMaze is sensitive to subtle and nuanced deficits in executive function even in preclinical AD.
Authors
- Dana L. Penney (ORCID: https://orcid.org/0000-0003-3105-6974)
- Jessie Fanglu Fu (ORCID: https://orcid.org/0000-0002-4970-7811)
- Jackson Thompson
- Talia L. Robinson (ORCID: https://orcid.org/0000-0002-5655-8324)
- M FARRELL
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- D. Rentz
- Grace A Del Carmen Montenegro
- KA Johnson
- Eva N Pintucci
- Randall Davis
- Michael J. Properzi
- Reisa A. Sperling
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Lahey Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108811
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00