Multi‐domain cognitive resilience to Alzheimer's Disease, Lewy Body and TDP‐43 neuropathologies

Cognitive resilience is associated with higher relative proportions of superficial excitatory cortical neurons and associated transcriptional programs that promote neurotrophic and adaptive responses. The gene expression patterns associated with resilience, however, differ across specific neuropathologies and cognitive domains. These findings provide insights into the cellular and molecular underpinnings of cognitive resilience and inform potential therapeutic targets for mitigating cognitive decline across diverse neuropathologies.