Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study
Question Can a quantitative biomarker from routine CT scans reliably stratify risk for clinically significant portal hypertension, overcoming limitations of current noninvasive methods? Findings Photon-counting CT-derived ECV accurately stratifies portal hypertension risk, offering high sensitivity (95%) for rule-in and high specificity (97%) for rule-out. Clinical relevance Integrating PCCT-ECV into routine surveillance CT provides an opportunistic, noninvasive tool for CSPH risk stratification, guiding timely patient management without requiring a separate examination.
Authors
- Daniel Kuetting (ORCID: https://orcid.org/0000-0001-6520-1020)
- Verena Tischler (ORCID: https://orcid.org/0000-0002-6673-8329)
- Julian Alexander Luetkens (ORCID: https://orcid.org/0000-0002-7715-4636)
- Tatjana Dell (ORCID: https://orcid.org/0000-0002-2835-8560)
- Dario Zocholl (ORCID: https://orcid.org/0000-0002-9218-6919)
- Claus Christian Pieper (ORCID: https://orcid.org/0000-0002-0893-1200)
- Narine Mesropyan (ORCID: https://orcid.org/0000-0002-5871-3965)
- Alexander Isaak (ORCID: https://orcid.org/0000-0003-2016-6166)
- Patrick Arthur Kupczyk (ORCID: https://orcid.org/0000-0001-9556-085X)
- Johannes Chang (ORCID: https://orcid.org/0000-0001-9635-8901)
- Bernhard T. Schmidt (ORCID: https://orcid.org/0000-0001-5894-6374)
- Abraham Jacob
- Christian Strassburg
- Christian Jansen
- Carsten Meyer
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- Siemens Healthineers (Germany) (DE)
Publication Details
- Journal
- European Radiology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1007/s00330-025-12222-8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00