Effects of a PSEN2 isogenic series on autophagy and Abeta production in iPSC‐derived neurons
These data show PSEN2 mutants have decreased gamma-secretase processivity, and suggest that mutations in PSEN2 cause imbalances in lysosome-associated proteostasis in human-derived neurons which may predispose neurodegeneration associated with age.
Authors
- Tatiana A. Giovannucci (ORCID: https://orcid.org/0000-0001-8978-6318)
- Gustavo Morrone Parfitt (ORCID: https://orcid.org/0000-0003-0168-4099)
- Ross W. Paterson (ORCID: https://orcid.org/0000-0001-9372-3635)
- Marcos Fernández (ORCID: https://orcid.org/0000-0002-6567-8547)
- Adriana Cunha
- Selina Wray
- Charlie Arber
Institutions
- Darent Valley Hospital (GB)
- UK Dementia Research Institute (GB)
- MRC Prion Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108908
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00