Lifetime Exposure to Estrogen Preserves Brain Health in Older Women in the IGNITE study
Our results support prior evidence that lifetime estrogen exposure is important for healthy brain aging, particularly with regard to brain volume. These findings have clinical implications for estrogen-based therapies throughout the lifespan. Understanding sex differences in AD is critical for developing sex-specific prevention strategies and treatments as part of a precision medicine approach.
Authors
- Shannon D. Donofry (ORCID: https://orcid.org/0000-0002-7394-1384)
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- George Grove (ORCID: https://orcid.org/0000-0002-5043-139X)
- Ankit Patel (ORCID: https://orcid.org/0000-0001-6812-1464)
- Haiqing Huang (ORCID: https://orcid.org/0000-0003-1240-6641)
- Lauren E. Oberlin (ORCID: https://orcid.org/0000-0001-9553-8070)
- Swathi Gujral (ORCID: https://orcid.org/0000-0003-4775-2106)
- A. Kramer
- William Guiler (ORCID: https://orcid.org/0000-0001-8696-0392)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Robyn A. Honea (ORCID: https://orcid.org/0000-0002-4661-2024)
- Sarah L. Aghjayan (ORCID: https://orcid.org/0000-0002-8597-2022)
- Amber Watts (ORCID: https://orcid.org/0000-0002-8385-1091)
- Chaeryon Kang (ORCID: https://orcid.org/0000-0001-9442-8515)
- Brad M. Sutton
- Eric Dennis Vidoni
- Charles H. Hillman
- Anna L. Marsland
- M. Ilyas Kamboh
- Edward McAuley
- Hayley Ripperger
Institutions
- Northeastern University (US)
- University of Kansas (US)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- AdventHealth Orlando (US)
- University of Illinois System (US)
- The University of Kansas Cancer Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University of Kansas Medical Center (US)
- Translational Research Institute for Metabolism and Diabetes (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108310
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00