A vascular component to the selective vulnerability of the medial temporal lobe in Alzheimer's disease
This study provides the first evidence of an artery-specific effect of vascular narrowing on key features of AD. It suggests that vascular health of the AChA might be critical in halting the progression of AD and that selective vulnerability of the MTL to tau pathology partly emerges from a compromised AChA.
Authors
- Christian Bocti (ORCID: https://orcid.org/0000-0003-2631-1387)
- Monica Sean (ORCID: https://orcid.org/0000-0002-9890-3413)
- Davy Vanderweyen (ORCID: https://orcid.org/0000-0002-8723-631X)
- Pascal Tétreault (ORCID: https://orcid.org/0000-0001-9061-0635)
- Félix Janelle (ORCID: https://orcid.org/0000-0002-9141-4692)
- Julia Huck (ORCID: https://orcid.org/0000-0002-5701-8506)
- Kevin Whittingstall (ORCID: https://orcid.org/0000-0002-9352-3438)
- Samantha Côté (ORCID: https://orcid.org/0000-0003-3165-5432)
- Vincent Doyon
Institutions
- Université de Sherbrooke (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098573
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00