White matter perivascular spaces are associated with lower phosphorylated tau and preserved cognitive function in Alzheimer’s Disease
These findings suggest that enlarged WM PVS are associated with lower peripheral pTau217 levels, which may contribute to preserved cognitive function in AD patients, but not in CVD patients. Understanding how PVS dynamics differ across neurodegenerative diseases could provide insight into their distinct origins and clinical consequences, guiding the development of targeted therapies.
Authors
- Robert Bartha (ORCID: https://orcid.org/0000-0002-7118-9096)
- Stephen R. Arnott (ORCID: https://orcid.org/0000-0002-0616-7771)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Julie Ottoy (ORCID: https://orcid.org/0000-0002-9879-7497)
- Malcolm A. Binns (ORCID: https://orcid.org/0000-0001-9998-6612)
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- William Z. Lin (ORCID: https://orcid.org/0000-0002-3610-5213)
- Yong‐Chuan Wong
- Jennifer S Rabin
- Si Won Ryoo
- Myuri Ruthirakuhan
- Sofia Perfetto
- Bradley J. MacIntosh
- Walter Swardfager
- Celine H.L. Huang
Institutions
- Western University (CA)
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Heart and Stroke Foundation (CA)
- Scarborough Health Network (CA)
- Health Sciences Centre (CA)
- Baycrest Hospital (CA)
- Robarts Clinical Trials (CA)
- Public Health Ontario (CA)
- Indoc Research (CA)
- Ontario Brain Institute (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108995
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00