Does <i>APOE4</i> genotype moderate the effects of multidomain exercise interventions in older individuals living with mild cognitive impairment?
Individuals with MCI and APOE4-positive status exhibit reduced responsiveness to multidomain interventions for global cognition, likely due to underlying genetic neurodegeneration.
Authors
- Laura Elizabeth Middleton (ORCID: https://orcid.org/0000-0001-8624-3123)
- Karen Li (ORCID: https://orcid.org/0000-0002-0261-743X)
- Amer M. Burhan (ORCID: https://orcid.org/0000-0002-9888-008X)
- Sarah Fraser (ORCID: https://orcid.org/0000-0003-4291-6298)
- Teresa Liu‐Ambrose
- Manuel Montero‐Odasso
- Quincy J Almeida
- Surim Son
- Frederico Pieruccini‐Faria
- Louis Bherer
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Vancouver Coastal Health (CA)
- University of British Columbia (CA)
- University of Waterloo (CA)
- University of Ottawa (CA)
- University of Toronto (CA)
- Parkwood Institute (CA)
- CARE Canada (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Research Institute for Aging (CA)
- Vancouver Coastal Health Research Institute (CA)
- Concordia University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_103664
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00